Institut Bergonié

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VINCO

inserm vinco u916
Validation et Identification de Nouvelles Cibles en Oncologie
Josy REIFFERS 

Etat des lieux des études promues par l'Institut Bergonié

 

 

 

 

Publications originales


Articles originaux

Bonnefoi H, Zaman K, Debled M, Fiche M, Fournier M, Nobahar M, Pierga JY, Koch KM, Bartlett J, Zimmer A, Marreaud S, Bogaerts J, Cameron D. An European Organisation for Research and Treatment of Cancer phase I study of lapatinib and docetaxel as neoadjuvant treatment for Human Epidermal Growth Factor Receptor 2 (HER2) positive locally-advanced/inflammatory or large operable breast cancer. Eur J Cancer 2013 ; 49 : 281-9 (IF : 5.061, SIGAPS : B).
 
Iggo R, Rudewicz J, Monceau E, Sévenet N, Bergh J, Sjoblom T, Bonnefoi H. Validation of a yeast functional assay for p53 mutations using clonal sequencing. J Pathol 2013 ; 231 : 441-8 (IF : 7.585, SIGAPS : A).
 
Lim JH, Iggo RD, Barker D. Models incorporating chromatin modification data identify functionally important p53 binding sites. Nucleic Acids Res 2013 ; 41 : 5582-93 (IF : 8.278, SIGAPS : A).
 
Vindrieux D, Augert A, Girard CA, Gitenay D, Lallet-Daher H, Wiel C, Le Calvé B, Gras B, Ferrand M, Verbeke S, de Launoit Y, Leroy X, Puisieux A, Aubert S, Perrais M, Gelb M, Simonnet H, Lambeau G, Bernard D. PLA2R1 mediates tumor suppression by activating JAK2. Cancer Res 2013 ; 73 : 6334-45 (IF : 8.65, SIGAPS : A).
 
 
André F, Bachelot T, Commo F, Campone M, Arnedos M, Dieras V, Lacroix-Triki M, Lacroix L, Cohen P, Gentien D, Adelaide J, Dalenc F, Goncalves A, Levy C, Ferrero JM, Bonneterre J, Lefeuvre C, Jimenez M, Filleron T, Bonnefoi H. Comparative genomic hybridisation array and DNA sequencing to direct treatment of metastatic breast cancer: a multicentre, prospective trial (SAFIR01/UNICANCER). Lancet Oncol 2013 ; doi: 10.1016/S1470- 2045(13)70611-9 [Epub ahead of print] (IF : 25.117, SIGAPS : A).
 
Cortazar P, Zhang L, Untch M, Mehta K, Costantino JP, Wolmark N, Bonnefoi H, Cameron D, Gianni L, Valagussa P, Swain SM, Prowell T, Loibl S, Wickerham DL, Bogaerts J, Baselga J, Perou C, Blumenthal G, Blohmer J, Mamounas EP, Bergh J, Semiglazov V,
 
Justice R, Eidtmann H, Paik S, Piccart M, Sridhara R, Fasching PA, Slaets L, Tang S, Gerber B, Geyer CE, Jr., Pazdur R, Ditsch N, Rastogi P, Eiermann W, von MG. Pathological complete response and
long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis. Lancet 2013 ; doi: 10.1016/S0140-6736(13)62422-8 [Epub ahead of print] (IF : 39.06, SIGAPS : A).
 
Bertucci F, Bouvier-Labit C, Finetti P, Métellus P, Adelaide J, Mokhtari K, Figarella-Branger D, Decouvelaere AV, Miquel C, Coindre JM, Birnbaum D. Gene expression profiling of solitary
fibrous tumors. PLoS One 2013 ; 8 : e64497 (IF : 3.73, SIGAPS : B).

Blay JY, Italiano A, Ray-Coquard I, Cesne A, Duffaud F, Rios M, Collard O, Bertucci F, Bompas E, Isambert N, Chaigneau L, Cassier P, Bui BN, Decanter G, Derbel O, Coindre JM, Zintl P, Badri N, Penel N. Long-term outcome and effect of maintenance therapy in patients with advanced sarcoma treated with trabectedin: an analysis of 181 patients of the French ATU compassionate use program. BMC Cancer 2013 ; 13 : 64 (IF :3.333, SIGAPS : C).

Bouvier C, Bertucci F, Métellus P, Finetti P, Maues de Paula A, Forest F, Mokhtari K, Miquel C, Birnbaum D, Vasiljevic A, Jouvet A, Coindre JM, Loundou A, Figarella-Branger D. ALDH1 is an immunohistochemical diagnostic marker for solitary fibrous tumours and haemangiopericytomas of the meninges emerging from gene profiling study. Acta Neuropathol Commun 2013 ; 1 : 10 (SIGAPS : NC).

Croce S, Hostein I, Ribeiro A, Garbay D, Velasco V, Stoeckle E, Guyon F, Floquet A, Neuville A, Coindre JM, MacGrogan G, Chibon F. YWHAE rearrangement identified by FISH and RTPCR
in endometrial stromal sarcomas: genetic and pathological correlations. Modern Pathol 2013 ; 26 : 1390-400 (IF : 5.253, SIGAPS : A).

Deyrup AT, Chibon F, Guillou L, Lagarde P, Coindre JM, Weiss SW. Fibrosarcoma-like lipomatous neoplasm: a reappraisal of so-called spindle cell liposarcoma defining a unique lipomatous
tumor unrelated to other liposarcomas. Am J Surg Pathol 2013 ; 37 : 1373-8 (IF : 4.868, SIGAPS : A).

Gits CM, van Kuijk PF, Jonkers MB, Boersma AW, Smid M, van Ijcken WF, Coindre JM, Chibon F, Verhoef C, Mathijssen RH, den Bakker MA, Verweij J, Sleijfer S, Wiemer EA. MicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR-145 AND miR-451 as tumor suppressors. Int J Cancer 2013 ; doi: 10.1002/ijc.28694 [Epub ahead of print] (IF : 6.198, SIGAPS : B).

Italiano A, Largarde P, Brulard C, Terrier P, Lae M, Marques B, Ranchère-Vince D, Michels JJ, Trassard M, Cioffi A, Piperno- Neumann S, Chevreau C, Blay JY, Delcambre C, Isambert N, Penel N, Bay JO, Bonvalot S, Coindre JM, Chibon F. Genetic profiling identifies two classes of soft-tissue leiomyosarcomas with distinct clinical characteristics. Clin Cancer Res 2013 ; 19 : 1190-6 (IF : 7.837, SIGAPS : A).

Lagarde P, Przybyl J, Brulard C, Pérot G, Pierron G, Delattre O, Sciot R, Wozniak A, Schöffski P, Terrier P, Neuville A, Coindre JM, Italiano A, Orbach D, Debiec-Rychter M, Chibon F. Chromosome instability accounts for reverse metastatic outcomes of pediatric and adult synovial sarcomas. J Clin Oncol 2013 ; 31 : 608-15 (IF : 18.038, SIGAPS : A).

Lindet C, Neuville A, Penel N, Lae M, Michels JJ, Trassard M, Terrier P, Birtwisle-Peyrottes I, Valo I, Collin F, Chateau MC, Robin YM, Coindre JM. Localised angiosarcomas: the identification of prognostic factors and analysis of treatment impact. A retrospective analysis from the French Sarcoma Group (GSF/ GETO). Eur J Cancer 2013 ; 49 : 369-76 (IF : 5.061, SIGAPS : B).

Mentzel T, Wiesner T, Cerroni L, Hantschke M, Kutzner H, Rutten A, Haberle M, Bisceglia M, Chibon F, Coindre JM. Malignant dermatofibroma : clinicopathological, immunohistochemical, and molecular analysis of seven cases. Modern Pathol 2013 ; 26 : 256-67 (IF : 5.253, SIGAPS : A).

Neuville A, Ranchère-Vince D, Paolo Dei Tos A, Montesco MC, Hostein I, Toffolatti L, Chibon F, Pissaloux D, Alberti L, Decouvelaere AV, Albert S, Rossi CR, Blay JY, Coindre JM. Impact of molecular analysis on the final sarcoma diagnosis: a study on 763 cases collected during a European epidemiological study. Am J Surg Pathol 2013 ; 37 : 1259-68 (IF : 4.868, SIGAPS : A).

Peille AL, Brouste V, Kauffmann A, Lagarde P, Le Morvan V, Coindre JM, Chibon F, Bresson-Bepoldin L. Prognostic value of PLAGL1-specific CpG site methylation in soft-tissue sarcomas. PLoS One 2013 ; 8 : e80741 (IF : 3.73, SIGAPS : B).

Pérot G, Mendiboure J, Brouste V, Velasco V, Terrier P, Bonvalot S, Guillou L, Ranchère-Vince D, Aurias A, Coindre JM, Chibon F. Smooth muscle differentiation identifies two classes of poorly
differentiated pleomorphic sarcomas with distinct outcome. Mod Pathol 2013 ; doi: 10.1038/modpathol.2013.205 [Epub ahead of print] (IF : 5.253, SIGAPS : A).

Robin YM, Penel N, Pérot G, Neuville A, Velasco V, Ranchère-Vince D, Terrier P, Coindre JM. Transgelin is a novel marker of smooth muscle differentiation that improves diagnostic accuracy
of leiomyosarcomas: a comparative immunohistochemical reappraisal of myogenic markers in 900 soft tissue tumors. Modern Pathol 2013 ; 26 : 502-10 (IF : 5.253, SIGAPS : A).

Rusakiewicz S, Semeraro M, Sarabi M, Desbois M, Locher C, Mendez R, Vimond N, Concha A, Garrido F, Isambert N, Chaigneau L, Le Brun-Ly V, Dubreuil P, Cremer I, Caignard A, Poirier-Colame V, Chaba K, Flament C, Halama N, Jager D, Eggermont A, Bonvalot S, Commo F, Terrier P, Opolon P, Emile JF, Coindre JM, Kroemer G, Chaput N, Le Cesne A, Blay JY, Zitvogel L. Immune infiltrates are prognostic factors in localized gastrointestinal stromal tumors. Cancer Res 2013 ; 73 : 3499- 510 (IF : 8.65, SIGAPS : A).

Simon-Keller K, Paschen A, Hombach AA, Strobel P, Coindre JM, Eichmuller SB, Vincent A, Gattenlohner S, Hoppe F, Leuschner I, Stegmaier S, Koscielniak E, Leverkus M, Altieri DC, Abken H, Marx A. Survivin blockade sensitizes rhabdomyosarcoma cells for lysis by fetal acetylcholine receptor-redirected T cells. Am J Pathol 2013 ; 182 : 2121-31 (IF : 4.522, SIGAPS : B).

Abraham I, MacDonald K, Tharmarajah S, Bokemeyer C, Ludwig H, Soubeyran P, Battistel V, Aapro M. Modeling of treatment response to erythropoiesis-stimulating agents in older (age>/=70years) and younger (age<70years) patients with cancer and anemia: findings from the Anemia Cancer Treatment study. J Geriatr Oncol 2013 ; 4 : 196-201 (IF : 1, SIGAPS : NC).

 Bellera C, Praud D, Petit-Monéger A, McKelvie-Sebileau P, Soubeyran P, Mathoulin-Pélissier S. Barriers to inclusion of older adults in randomised controlled clinical trials on Non-
Hodgkin’s lymphoma: a systematic review. Cancer Treat Rev 2013 ; 39 : 812-7 (IF : 6.024, SIGAPS : B).
 
Chodoeva A, Bosc JJ, Lartigue L, Guillon J, Auzanneau C, Costet P, Zurdinov A, Jarry C, Robert J. Antitumor activity of semisynthetic derivatives of Aconitum alkaloids. Invest New Drugs 2013 ; doi: 10.1007/s10637-013-9986-z [Epub 2013 Jun 13] (IF : 3.498, SIGAPS : C).
 
Deghrigue M, Dellai A, Akremi N, Le Morvan V, Robert J, Bouraoui A. Evaluation of antiproliferative and antioxidant activities of the organic extract and its polar fractions from the
Mediterranean gorgonian Eunicella singularis. Environ Toxicol Pharmacol 2013 ; 36 : 339-46 (IF : 2.005, SIGAPS : D).
 
Dellai A, Dridi D, Le Morvan V, Robert J, Cherif A, Mosrati R, Mansour HB. Decolorization does not always mean detoxification: case study of a newly isolated Pseudomonas peli for decolorization of textile wastewater. Environ Sci Pollut Res Int 2013 ; 20 : 5790-6 (IF : 2.618, SIGAPS : C).
 
Dellai A, Laajili S, Le Morvan V, Robert J, Bouraoui A. Antiproliferative activity of phenolics of the Mediterranean seaweed Laurencia robusta. Indust Crops Products 2013 ; 47 : 252-5 (SIGAPS : NC).
 
Dubois J, Etienne G, Laroche-Clary A, Lascaux A, Bidet A, Lippert E, Ait-Ouferoukh S, Saada V, Micol JB, Bouabdallah K, Robert J. Identification of methylguanine methyltransferase polymorphisms as genetic markers of individual susceptibility to therapy-related myeloid neoplasms. Eur J Cancer 2013 ; doi : 10.1016/j.ejca.2013.10.012 [Epub 2013 Nov 14] (IF : 5.061, SIGAPS : B).
 
Durán RV, MacKenzie ED, Boulahbel H, Frezza C, Heiserich L, Tardito S, Bussolati O, Rocha S, Hall MN, Gottlieb E. HIFindependent role of prolyl hydroxylases in the cellular response to amino acids. Oncogene 2013 ; 32 : 4549-56 (IF : 7.357, SIGAPS : A).
 
François A, Auzanneau C, Le Morvan V, Galaup C, Godfrey HS, Marty L, Boulay A, Artigau M, Mestre-Voegtlé B, Leygue N, Picard C, Coulais Y, Robert J, Benoist E. A functionalized heterobimetallic 99mTc/Re complex as a potential dual modality imaging probe: synthesis, photophysical properties, cytotoxicity and cellular imaging investigations. Dalton Trans 2013 ; 43 : 439-50 (IF : 3.806, SIGAPS : B).
 
Gachard N, Parrens M, Soubeyran I, Petit B, Marfak A, Rizzo D, Devesa M, Delage-Corre M, Coste V, Laforet MP, de Mascarel A, Merlio JP, Bouabdhalla K, Milpied N, Soubeyran P, Schmitt A, Bordessoule D, Cogne M, Feuillard J. IGHV gene features and MYD88 L265P mutation separate the three marginal zone lymphoma entities and Waldenström macroglobulinemia/ lymphoplasmacytic lymphomas. Leukemia 2013 ; 27 : 183-9 (IF : 10.164, SIGAPS : A).

Krifa M, Dellai A, Bouhlel I, Robert J, Cherif A, Barillier D, Mosrati R, Chekir-Ghedira L, Ben Mansour H. Human cell death in relation to DNA damage after exposure to the untreated and
biologically treated pharmaceutical wastewater. Environ Sci Pollut Res Int 2013 ; 20 : 3836-42 (IF : 2.618, SIGAPS : C).
 
Lartigue L, Faustin B. Mitochondria: metabolic regulators of innate immune responses to pathogens and cell stress. Int J Biochem Cell Biol 2013 ; 45 : 2052-6 (IF : 4.152, SIGAPS : B).

Malleter M, Tauzin S, Bessède A, Castellano R, Goubard A, Godey F, Levêque J, Jézéquel P, Campion L, Campone M, Ducret T, MacGrogan G, Debure L, Collette Y, Vacher P, Legembre P. CD95L cell surface cleavage triggers a prometastatic signaling pathway in triple-negative breast cancer. Cancer Res 2013 ; 73 : 6711-21 (IF : 8.65, SIGAPS : A).
 
Morschhauser F, Radford J, van Hoof A, Botto B, Rohatiner AZ, Salles G, Soubeyran P, Tilly H, Bischof-Delaloye A, van Putten WL, Kylstra JW, Hagenbeek A. 90Yttrium-ibritumomab tiuxetan consolidation of first remission in advanced-stage follicular non-Hodgkin lymphoma: updated results after a median followup of 7.3 years from the international, randomized, phase III first-line indolent trial. J Clin Oncol 2013 ; 31 : 1977-83 (IF : 18.038, SIGAPS : A).

Puyo S, Montaudon D, Pourquier P. From old alkylating agents to new minor groove binders. Crit Rev Oncol Hematol 2013 ; doi: 10.1016/j.critrevonc.2013.07.006 [Epub 2013 Aug 20] (IF : 4.637, SIGAPS : B).
 
Rey C, Soubeyran I, Mahouche I, Pédeboscq S, Bessède A, Ichas F, De Giorgi F, Lartigue L. HIPK1 drives p53 activation to limit colorectal cancer cell growth. Cell Cycle 2013 ; 12 : 1879- 91 (IF : 5.243, SIGAPS : B).
 
Rullier A, Gourgou-Bourgade S, Jarlier M, Bibeau F, Chassagne-Clément C, Hennequin C, Tisseau L, Leroux A, Ettore F, Peoc’h M, Diebold MA, Robin YM, Kleinclaus I, Mineur L, Petitjean C, Mosnier JF, Soubeyran I, Padilla N, Lemaistre AI, Berille J, Denis B, Conroy T, Gérard JP. Predictive factors of positive circumferential resection margin after radiochemotherapy for rectal cancer: the French randomised trial ACCORD12/0405 PRODIGE 2. Eur J Cancer 2013 ; 49 : 82-9 (IF : 5.061, SIGAPS : B).

Cas cliniques
 Le Jeune S, Des Guetz G, Bihan H, Cohen R, Coindre JM, Mourad JJ. Refractory hypoglycemia controlled by sorafenib in solitary fibrous tumor. J Clin Oncol 2013 ; 31 : e118-e121 (IF : 18.038, SIGAPS : A).
 
Gastaud L, Saada-Bouzid E, Le Morvan V, Pourquier P, Ianessi A, Thariat J, Italiano A, Thyss A. Major efficacy of trabectedin in 2 metastatic osteosarcoma patients with wild-type Asp1104 ERCC5 tumor status. Onkologie 2013 ; 36 : 670-3 (IF : 1, SIGAPS : E).

Meyer M, Godbert Y, Soubeyran I, Cazeau AL, Bonichon F. Benign cystic mesothelioma: false-positive iodine accumulation in a patient with oncocytic follicular thyroid carcinoma. Clin Nucl Med 2013 ; doi: 10.1097/RLU.0b013e3182a75664 (IF : 2.955, SIGAPS : B).
 
Revues générales
Chibon F. Cancer gene-expression signatures. The rise and fall? Eur J Cancer 2013 ; 49 : 2000-9 (IF : 5.061, SIGAPS : B).
 
Robert J. mTOR, une protéine multifonctionnelle impliquée (entre autres) dans l’angiogenèse. VEGF Actu 2013 ; n° 33 : 9-16.
 
Robert J. Biologie de la métastase. Bull Cancer 2013 ; 100 : 333- 42 (IF : 0.605, SIGAPS : E).

Conférences sur invitation - Nationales

Djavaheri-Mergny M. Régulation de l’autophagie au cours de la différenciation des cellules leucémiques : rôles des protéines Beclin 1 et Sequestosome 1/p62. CRCT-INSERM U1037. Toulouse, juin 2013.

Robert J. Historique et apport de la médecine personnalisée en pratique. Présentation à l’Atelier «Médecine personnalisée : enjeux et défis» des Rencontres de la Cancérologie Française. Lyon, 6-7 novembre 2013.
 
Robert J. Tests compagnons vs. Analyse du génome entier : comment définir des tests prédictifs en oncologie ? 3e Conférence annuelle «Biomarqueurs 2014» organisée par le Development Institute International. Paris, 26 novembre 2013

Conférences sur invitation - Internationales

Iggo R. TOX3, un nouveau gène de prédisposition au cancer du sein. 15e Colloque de la Recherche de la Ligue contre le Cancer. Nice, janvier 2013.

Durán RV. Glutaminolysis activates mTORC1 signaling. Workshop : «The hemato-vascular system: development and disease». Baeza, Spain. October 21, 2013.

Durán RV. Regulation of mTOR signaling by glutamine metabolism. Department of Physiology, Université de Lausanne,
Lausanne, Switzerland. January 11, 2013.
 
Soubeyran P. Geriatric assessment and their clinical applications : Nutrition. 17th European Cancer Congress/ESMO. Amsterdam, October 1st, 2013.
 
Soubeyran P. National organization of Geriatric Oncology Care: the French model. International Society of Geriatric Oncology (SIOG). Copenhagen, October 25, 2013.

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