| Serge EVRARD trained in general medicine in Nancy (1978-1984) and received his diploma in visceral surgery in Strasbourg (1985-1990). He then received his PhD in Sciences at the University Paris VII and his Accreditation to Supervise Research in 1993. He was awarded University Professor – Hospital Practitioner in 1994. In 1999, he was appointed coordinator of the Digestive Group at the Institut Bergonié. Current responsibilities: He is Professor in Cancerology (surgery) at the University Bordeaux Segalen. At Institut Bergonié, he coordinates the Group for Digestive Tumours, as well as the Department of Surgery. On the International level: he is a member of the executive board of the European Society of Surgical Oncology (ESSO), for which he organised the 15th congress in Bordeaux. He participates in EORTCC-GI projects. National level: he currently chairs the French Society of Cancer (2010-2011) as well as the French Society of Surgical Oncology (including the Club for Comprehensive Cancer Centres (CLCC) Surgeons). He is a co-founding member of the National Council of Cancerology. He is involved in the projects of the French Federation of CLCC’s Strategic Orientation Council. |
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TREATMENT
Professor Evrard is specialised in the management of digestive tumours, except for oesophagus tumours: stomach, small intestine, colon, rectum, anus, liver, pancreas, and peritoneum. He consults every Tuesday and Friday afternoons by appointment ((+33) 5 56 33 32 61 / Cette adresse email est protégée contre les robots des spammeurs, vous devez activer Javascript pour la voir. ). He contributes to Multidisciplinary Meetings (RCP) for Digestive Tumours (lien à la composition de RCP) which meets every Monday and Thursday evening. In addition to this first-line patient care, he manages consultations and follow-up RCPs for the entire Aquitaine region, in accordance with the provisions of the Cancer Plan 2 for cases that are complex from the outset and relapse situations (hepatic metastases, rectal cancer, peritoneal carcinomas, pancreas,etc).
RESEARCH ACTIVITIES
He coordinates the programme of integrated research “Chronicisation de la maladie métastatique colorectale” supported by the Group for Digestive Tumours. In particular, he develops surgical programmes in association with other programmes in medicine, radiology, biology (INSERM VINCO Unit) and social and human sciences.
For hepatic metastases in colorectal cancer, the ARF2003 protocol (lien) (PHRC 2003) enabled us to establish the first prospective series of non resectable lesions, surgically resected and removed by radiofrequency ablation. The per-operative high-intensity focused ultrasound (HIFU) therapy is now considered in clinical research programmes as a curative procedure which enables the treatment of more patients, especially those presenting complex and numerous lesions. These results received a prize for the best scientific contribution during the congress of the international society of hepatobiliary and pancreatic surgery in Cape Town in April 2011.
The ULIIS trial (lien), started in June 2001, will try to define to what extent the addition of a contrast agent can help modify per-operative liver ultrasonography in order to be able to find small lesions that chemotherapy could have removed without however completely eradicating them. Furthermore, thanks to this trial we will obtain the first quantitative and qualitative contact images of the metastatic vascularisation after different types of targeted induction therapies.
As the regional referral centre for peritoneal metastases (carcinomatosis), the Digestive Group conducts an original trial, COCHISE (lien), which studies the combination of a radical and complete surgery to a strong chemotherapy doubled with an antibody blocking the cells in replication. In order to dismiss useless aggressive treatments (referred to as “therapeutic de-escalation”), the addition of a hyperthermic intraperitoneal chemotherapy is withdrawn in this pilot study, thus renovating the therapeutic concept.
Huge progress has been made over these last 20 years for rectal cancer, as the pelvic relapse risk has decreased from 30% to less than 5% thanks to a better surgical technique and to radiotherapy progress. Although medium and low rectal cancers are nowadays treated, the morbidity and the change of quality of life are still important. A new type of restoration of intestinal continuity after complete removal of the rectum, delayed coloanal anastomosis could help reduce morbidity and above all eliminate the systematic resort to a preventive temporary artificial anus. In addition, this intervention is far less expensive.
The Digestive Group has just launched the CASCADOR trial (link), which will attempt to demonstrate the utility of this technique on a prospective multicentre basis.
In order to improve the quality of life of patients operated for rectal cancer, the Digestive Group studies the consequences of the radiotherapeutic and surgical treatment on erectile function. The METEORR protocol (lien), using to a polysomnographic recording, can discriminate functional disorders treatable by drugs for organic disorders requiring intracavernous injections. The early diagnosis of these disorders enables us to prevent the permanent installation of erectile disorders and directs their management.
Other academic or industrial trials are currently open at Institut Bergonié regarding the surgery of digestive tumours. A regularly updated list of these trials is available here.
TEACHING ACTIVITIES
Prof. Serge Evrard teaches at the Medical School of University Bordeaux Segalen.
He is in charge of the Inter-University Diploma of Oncological Surgical practices in association with the Universities of Lyon, Nancy, Dijon, Marseille, Toulouse, Nantes, and Genoa. He also teaches in the Diploma of Specialised Studies in General Surgery and for the Postgraduate Diploma in Oncology. He is also involved in the training of accredited nurses. He participates in many postgraduate teaching activities and organises the“Management of colorectal liver metastases” advanced European class of the ESSO in partnership with the Professor Graeme Poston from Liverpool University. (lien)
He just joined the teaching staff of the joint ECCO, AACR, EORTC, and ESMO workshop: "Methods in Clinical Cancer Research" in Flims.
